This form occurs predominantly at children and young adults. This form is immune mediated and insulin dependent. The cells that produce insulin known as pancreatic B cells fail to respond all stimuli (stimuli to insulin production) because they are attacked by immune system and the rate of destruction is quite variable. That means the patients need exogenous insulin because the circulating insulin is usually absent. Excessive of appetite, excessive production of urine, abnormal thirst, weight loss, prone to ketoacidosis are common symptoms of type I Diabetes mellitus. There are many factors that can promote ketoacidosis such as:
- Fever
- Infection
- Pregnancy
- Others conditions that increase basal metabolism
On those conditions the cells have to eat more but they can not use glucose, so they use fat for their need, and fat metabolism produces ketones.
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